Table 2. Indicators related to necroinflammation in CHC patients in univariate and multivariate analyses.
| Variable | G<2 (n = 17) | G≥2 (n = 103) | P value | OR (95% CI) |
| Age, yrs | 50.41±8.42 | 51.48±7.17 | 0.83 | |
| Male, n (%) | 3 (17.65) | 54 (52.43) | 0.01 | |
| ALT (U/L) | 29.34±17.66 | 65.55±75.00 | <0.001 | |
| AST (U/L) | 27.49±10.18 | 51.32±46.83 | <0.001 | 1.07 (1.01–1.13) |
| TBIL (µmol/L) | 13.40±4.47 | 17.02±7.50 | 0.05 | |
| DBIL (µmol/L) | 2.89±1.14 | 3.32±1.39 | 0.21 | |
| TP (g/L) | 69.84±3.65 | 71.11±5.12 | 0.33 | |
| Albumin (g/L) | 44.34±1.84 | 43.02±2.40 | 0.03 | |
| Globulin (g/L) | 26.08±3.57 | 29.70±18.57 | 0.03 | |
| GGT (U/L) | 16.49±10.89 | 22.95±17.12 | 0.01 | |
| ALP (U/L) | 75.35±18.52 | 76.44±21.36 | 0.58 | |
| TBA (µmol/L) | 4.57±2.75 | 12.34±50.41 | 0.04 | |
| Cholinesterase (U/L) | 7541.44±2140.99 | 6860.64±1281.44 | 0.03 | |
| PTA (%) | 98.47±6.30 | 91.40±9.14 | 0.002 | 0.89 (0.81–0.98) |
| Cer(d18∶1/18∶1) (pmol/mL) | 3.85±1.11 | 3.30±1.33 | 0.03 | |
| HexCer(d18∶1/16∶0) (pmol/mL) | 1131.87±525.58 | 1324.62±493.48 | 0.03 | |
| HexCer(d18∶1/22∶0) (pmol/mL) | 250.11±46.82 | 308.01±85.18 | 0.01 | 1.01 (1.00–1.02) |
| HexCer(d18∶1/24∶1) (pmol/mL) | 372.25±106.73 | 483.20±175.46 | 0.001 | |
| HexCer(d18∶1/24∶0) (pmol/mL) | 307.86±61.45 | 376.58±103.94 | 0.01 |
Data are means ± SD or number of patients (%).
P values are acquired by independent-samples t test or the Mann-Whitney test for continuous variables depending on the data distribution, and by Pearson χ2 for categoric variables.
OR: odds ratio; CI: confidence interval; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TBIL: total bilirubin; DBIL: direct bilirubin; TP: total protein; GGT: γ-glutamyl transpeptidase; ALP, alkaline phosphatase; TBA: total bile acid; PTA: prothrombin activity; Cer: ceramide; HexCer: hexosylceramide.