Table 3. Indicators related to necroinflammation (G≥2) in CHC patients with normal ALT in univariate and multivariate analyses.
| Variable | G<2 (n = 14) | G≥2 (n = 50) | P value | OR (95% CI) |
| Age, yrs | 49.29±8.84 | 51.84±6.97 | 0.26 | |
| Male, n (%) | 1(7.14) | 18(36.00) | 0.08 | |
| AST (U/L) | 24.13±7.44 | 30.86±8.61 | 0.01 | |
| TBIL (µmol/L) | 12.53±4.15 | 17.48±8.40 | 0.02 | |
| DBIL (µmol/L) | 2.67±1.10 | 3.24±1.36 | 0.11 | |
| TP (g/L) | 70.24±3.32 | 71.10±5.39 | 0.58 | |
| Albumin (g/L) | 44.60±1.83 | 43.17±2.36 | 0.04 | |
| Globulin (g/L) | 26.35±3.53 | 27.98±4.23 | 0.19 | |
| GGT (U/L) | 12.97±4.27 | 16.61±7.31 | 0.03 | |
| ALP (U/L) | 74.98±20.09 | 71.10±13.91 | 0.41 | |
| TBA (µmol/L) | 4.21±2.43 | 6.54±4.72 | 0.10 | |
| Cholinesterase (U/L) | 7546.39±2232.91 | 6884.89±1437.77 | 0.19 | |
| PTA (%) | 99.59±6.18 | 93.39±10.04 | 0.02 | |
| HexCer(d18∶1/16∶0) (pmol/mL) | 1079.01±495.41 | 1271.33±390.77 | 0.05 | |
| HexCer(d18∶1/22∶0) (pmol/mL) | 236.83±40.12 | 315.53±90.33 | <0.001 | 1.02(1.01–1.03) |
| HexCer(d18∶1/24∶1) (pmol/mL) | 340.53±86.46 | 490.90±189.20 | <0.001 | |
| HexCer(d18∶1/24∶0) (pmol/mL) | 291.15±50.55 | 377.49±102.57 | <0.001 | |
| dhCer(d18∶0/24∶1) (pmol/mL) | 35.10±11.78 | 48.48±22.56 | 0.05 |
Data are means ± SD or number of patients (%).
P values are acquired by independent-samples t test or the Mann-Whitney test for continuous variables, and by Pearson χ2 for categoric variables.
OR: odds ratio; CI: confidence interval; AST: aspartate aminotransferase; TBIL: total bilirubin; DBIL: direct bilirubin; TP: total protein; GGT: γ-glutamyl transpeptidase; ALP, alkaline phosphatase; TBA: total bile acid; PTA: prothrombin activity; Cer: ceramide; HexCer: hexosylceramide; dhCer: dihydroceramide.