Table 1. Evaluation of stress response in the congenic strains.
| Strain | ||||
| Parameters | SHRSP | SPwch1.71 | SPwch1.72 | WKY |
| BP (mmHg) | 213±31 (4) | 209±19 (4) | 212±24 (4) | 111±10*(6) |
| ΔBP (mmHg), Restraint | 22.4±11.8 (4) | 33.8±8.1 (4) | 2.0±3.3*(4) | 4.1±5.7*(6) |
| Cold | 34.4±4.3 (4) | 48.1±17.7 (4) | 15.7±6.1*(4) | 17.3±8.1*(6) |
| HR (bpm) | 331±71 (3) | 272±21 (4) | 348±40 (4) | 343±18 (6) |
| ΔHR (bpm), Restraint | 67.2±18.4 (3) | 100.1±20.9 (4) | 102.1±10.9*(4) | 33.3±20.3*(6) |
| Cold | 179.0±32.6 (3) | 189.2±27.0 (4) | 96.9±60.0 (4) | 127.1±20.0*(6) |
| ΔLF/HF, Restraint | 3.38±0.51 (5) | 3.35±1.00 (5) | 1.92±1.11*(5) | 0.34±0.30*(5) |
| ΔNE (µmol), Cold | 0.572±0.096 (10) | 0.596±0.061 (10) | 0.341±0.046*(10) | 0.173±0.069*(16) |
Baseline blood pressure (BP), heart rate (HR), increase in BP (ΔBP), HR (ΔHR), LF/HF (ΔLF/HF, a parameter for the relative sympathetic activity), and changes in urinary norepinephrine excretion (ΔNE) under cold and restraint stress in SHRSP were compared with those in SPwch1.71,SPwch1.72 and WKY [5]. The numbers of rats used for each analysis are shown in parentheses. *P<0.05 vs. SHRSP by Dunnett’s post-hoc test.