Table 1.
Odds ratios for the association of the MITF E318K variant with melanoma risk in strata of other melanoma risk factors.
| Variables | Strata | Variant Status | Odds Ratio (95% CI)1 for melanoma associated with MITF variant | P-value for interacti on | |||
|---|---|---|---|---|---|---|---|
| Cases | Controls | ||||||
| Variant− N (%) |
Variant+ N (%) |
Variant− N (%) |
Variant+ N (%) |
||||
| MITF | All subjects | 1150 (96.3) | 44 (3.7) | 2377 (97.8) | 53 (2.2) | 1.7 (1.1, 2.6) | NA |
|
| |||||||
| Eye color | Blue | 532 (97.8) | 12 (2.2) | 987 (98.3) | 17 (1.7) | 1.2 (0.5, 2.6) | |
| Other | 618 (95.1) | 32 (4.9) | 1390 (97.5) | 36 (2.5) | 2.1 (1.2, 3.5) | 0.25 | |
|
| |||||||
|
| |||||||
| Hair Color | Black/dark brown | 291 (95.7) | 13 (4.3) | 754 (98.6) | 11 (1.4) | 3.8 (1.5, 9.6) | |
| light brown/blond | 727 (97.1) | 22 (2.9) | 1393 (97.6) | 35 (2.4) | 1.0 (0.6, 1.8) | ||
| red | 127 (93.4) | 9 (6.6) | 207 (97.6) | 5 (2.4) | 3.1 (0.9, 10.8) | 0.03 | |
|
| |||||||
| Skin color | Olive | 92 (97.9) | 2 (2.1) | 320 (98.8) | 4 (1.2) | 1.9 (0.2, 14.2) | |
| Fair | 793 (96.4) | 30 (3.6) | 1597 (98.2) | 30 (1.8) | 2.2 (1.2, 3.8) | ||
| Very fair | 263 (95.6) | 12 (4.4) | 450 (95.9) | 19 (4.1) | 0.9 (0.4, 2.0) | 0.23 | |
|
| |||||||
| Moles | None | 254 (94.4) | 15 (5.6) | 564 (99.1) | 5 (0.9) | 5.9 (1.9, 18.0) | |
| Few | 551 (97.0) | 17 (3.0) | 1207 (97.4) | 32 (2.6) | 1.1 (0.6, 2.1) | ||
| Moderate | 233 (96.7) | 8 (3.3) | 359 (97.5) | 9 (2.5) | 1.5 (0.5, 4.5) | ||
| Many | 75 (96.2) | 3 (3.8) | 114 (96.6) | 4 (3.4) | 1.2 (0.2, 7.0) | <0.01 | |
|
| |||||||
| Propensity to Burn | Low | 575 (97.0) | 18 (3.0) | 1319 (98.2) | 24 (2.8) | 1.7 (0.9, 3.4) | |
| High | 548 (95.8) | 24 (4.2) | 1003 (97.3) | 28 (2.7) | 1.7 (0.9, 3.0) | 0.97 | |
|
| |||||||
| Inability to Tan | No | 602 (97.4) | 16 (2.6) | 1377 (98.3) | 24 (1.7) | 1.5 (0.8, 3.1) | |
| Yes | 521 (95.1) | 27 (4.9) | 945 (97.3) | 26 (2.7) | 1.9 (1.0 3.5) | 0.62 | |
|
| |||||||
| Freckling in youth | None | 451 (95.4) | 22 (4.6) | 1018 (97.8) | 23 (2.2) | 2.3 (1.1, 4.5) | |
| Some | 673 (97.1) | 20 (2.9) | 1244 (97.9) | 27 (2.1) | 1.4 (0.7, 2.5) | 0.22 | |
|
| |||||||
| Family History of Melanoma | None | 875 (96.2) | 35 (3.8) | 2051 (98.0) | 42 (2.0) | 1.9 (1.2, 3.2) | |
| Present | 251 (96.9) | 8 (3.1) | 288 (96.3) | 11 (3.7) | 0.8 (0.3, 2.1) | 0.11 | |
|
| |||||||
| Personal History of NMSC | None | 588 (96.5) | 21 (3.5) | 1814 (97.9) | 38 (2.1) | 1.5 (0.7, 3.1) | |
| Present | 541 (96.1) | 22 (3.9) | 536 (97.3) | 15 (2.7) | 1.7 (0.9, 3.0) | 0.96 | |
|
| |||||||
| MC1R | No MC1R variant | 146 (98.0) | 3 (2.0) | 363 (98.4) | 6 (1.6) | 1.09 (0.24, 4.99) | |
| Any MCIR variant | 903 (96.1) | 37 (3.9) | 1770 (97.6) | 44 (2.4) | 1.65 (1.01, 2.69) | 0.55 | |
1
Odds ratio and 95% CI adjusted for age, sex, center and age*sex interaction.