Table 2.
Gene | dbSNP ID (Gene Location) | Alleles | African American | European American | ||||
---|---|---|---|---|---|---|---|---|
| ||||||||
Allele Freq | SQ | FTND | Allele Freq | SQ | FTND | |||
CHRNA2 | rs2292976 (Exon 8) | A/G | 0.13/0.87 | 0.120a | 0.0866a | 0.14/0.86 | −0.902a | −0.664a |
0.0578d | 0.0461d | 0.502d | 0.631d | |||||
−0.444r | −0.700r | −0.0378r | −0.0221r | |||||
| ||||||||
rs3735757 (Intron 5) | G/C | 0.22/0.78 | −0.378a | −0.613a | 0.14/0.86 | −0.589a | −0.291a | |
−0.635d | −0.810d | 0.750d | −0.891d | |||||
−0.239r | −0.464r | −0.00782r | −0.00675r | |||||
| ||||||||
rs891398 (Exon 5) | T/C (T125A) | 0.25/0.75 | 0.0201a | 0.00790a | 0.52/0.48 | −0.511a | −0.450a | |
0.026d | 0.0287d | 0.228d | 0.294d | |||||
0.302r | 0.0814r | −0.0357r | −0.0338r | |||||
| ||||||||
rs2472553 (Exon 2) | T/C (T22I) | 0.16/0.84 | 0.481a | 0.534a | 0.13/0.87 | −0.595a | −0.192a | |
0.324d | 0.387d | 0.776d | −0.724d | |||||
−0.538r | −0.649r | −0.00429r | −0.000863r | |||||
| ||||||||
CHRNA6 | rs9298628 (3′-flanking) | C/T | 0.25/0.75 | −0.422a | −0.375a | 0.81/0.19 | −0.0455a | −0.216a |
−0.266d | −0.232d | −0.336d | −0.547d | |||||
−0.913r | −0.996r | −0.0625r | −0.251r | |||||
| ||||||||
rs892413 (Intron 2) | C/A | 0.25/0.75 | −0.612a | −0.397a | 0.80/0.20 | −0.00769a | −0.152a | |
−0.566d | −0.340d | −0.117d | −0.189d | |||||
−0.704r | −0.732r | −0.0195r | −0.304r | |||||
| ||||||||
rs2217732 (Intron 2) | A/G | 0.26/0.74 | −0.423a | −0.405a | 0.81/0.19 | −0.0195a | −0.126a | |
−0.247d | −0.215d | −0.335d | −0.433d | |||||
−0.972r | 0.864r | −0.0235r | −0.163r |
Notes: (1) Superscripts indicate genetic model used for analysis: a = additive; d = dominant; and r = recessive. (2) For each ethnic-specific sample, age and sex were used as covariates. (3) Negative signs indicate protective effect with the model specified in superscript letters.