Skip to main content
. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Hum Genet. 2013 Nov 20;133(5):575–586. doi: 10.1007/s00439-013-1398-9

Table 2.

ND-associated p values under the three genetic models for the first given allele of each SNP in CHRNA2 and CHRNA6 in the discovery family sample

Gene dbSNP ID (Gene Location) Alleles African American European American

Allele Freq SQ FTND Allele Freq SQ FTND
CHRNA2 rs2292976 (Exon 8) A/G 0.13/0.87 0.120a 0.0866a 0.14/0.86 −0.902a −0.664a
0.0578d 0.0461d 0.502d 0.631d
−0.444r −0.700r −0.0378r −0.0221r

rs3735757 (Intron 5) G/C 0.22/0.78 −0.378a −0.613a 0.14/0.86 −0.589a −0.291a
−0.635d −0.810d 0.750d −0.891d
−0.239r −0.464r −0.00782r −0.00675r

rs891398 (Exon 5) T/C (T125A) 0.25/0.75 0.0201a 0.00790a 0.52/0.48 −0.511a −0.450a
0.026d 0.0287d 0.228d 0.294d
0.302r 0.0814r −0.0357r −0.0338r

rs2472553 (Exon 2) T/C (T22I) 0.16/0.84 0.481a 0.534a 0.13/0.87 −0.595a −0.192a
0.324d 0.387d 0.776d −0.724d
−0.538r −0.649r −0.00429r −0.000863r

CHRNA6 rs9298628 (3′-flanking) C/T 0.25/0.75 −0.422a −0.375a 0.81/0.19 −0.0455a −0.216a
−0.266d −0.232d −0.336d −0.547d
−0.913r −0.996r −0.0625r −0.251r

rs892413 (Intron 2) C/A 0.25/0.75 −0.612a −0.397a 0.80/0.20 −0.00769a −0.152a
−0.566d −0.340d −0.117d −0.189d
−0.704r −0.732r −0.0195r −0.304r

rs2217732 (Intron 2) A/G 0.26/0.74 −0.423a −0.405a 0.81/0.19 −0.0195a −0.126a
−0.247d −0.215d −0.335d −0.433d
−0.972r 0.864r −0.0235r −0.163r

Notes: (1) Superscripts indicate genetic model used for analysis: a = additive; d = dominant; and r = recessive. (2) For each ethnic-specific sample, age and sex were used as covariates. (3) Negative signs indicate protective effect with the model specified in superscript letters.