. Author manuscript; available in PMC: 2014 May 1.

Published in final edited form as: Hum Genet. 2013 Nov 5;133(5):499–508. doi: 10.1007/s00439-013-1389-x

Table 2.

Allelic association of SNP rs1122608 with stroke in the Chinese Han population

Study population	Sample size	P_hwe	Chi-square test				Logistic regression analysis
Study population	Case/control	P_hwe	Minor allele	Frequency	P_obs	OR (95 % CI)	P_adj	OR (95 % CI)
Cohort I (China-Central)	1,075/2,685	0.83	T	0.073/0.10	3.31E–04	0.71 (0.59–0.86)	2.10E–04	0.61 (0.47–0.80)
Cohort II (China-North)	1,208/824	0.18	T	0.088/0.12	2.63E–03	0.73 (0.59–0.90)	6.00E–03	0.69 (0.54–0.90)
Combined	2,283/3,509	0.36	T	0.081/0.10	3.57E–05	0.76 (0.67–0.87)	7.86E–05	0.73 (0.62–0.85)

Frequency frequency of the risk allele in case group/control groups, OR odds ratio; 95 % CI 95 % confidential interval

P_hwe, P value for Hardy–Weinberg equilibrium (HWE) tests using PLINK version 1.07

P_obs, P value for association before adjusting for covariates by 2 × 2 contingence tables using PLINK version 1.07

P_adj, P value for association after adjusting for covariates sex, age, Hyperion, smoking, LDL-C, HDL-C, TC and TG by multiple logistic regression analysis using SPSS v17.0