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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Acta Neuropathol. 2013 Nov 17;127(5):731–745. doi: 10.1007/s00401-013-1212-8

Fig. 1. Transcriptome profiling reveals two posterior fossa EPN sub-groups.

Fig. 1

Unbiased hierarchical clustering of 44 primary EPN samples based on the top 5% of variant genes (n=883) reveals a distinct supratentorial (ST) located tumor sub-group (green) and 2 posterior fossa (PF) subgroups designated Group A1 (red) and B1 (blue). Four samples fell outside of the 3 main clusters and were excluded from further analyses. Below Groups A1 and B1 are a heatmap of NELL2 and LAMA2 expression and color-coded bars to indicate histologic grade (WHO grade II = yellow; WHO grade III = orange), recurrence (recurrent = dark green, non-recurrent = light green), and survival (died of disease = maroon, alive = pink).