Table 1.
CN (n=92) |
MCI (n=149) |
AD (n=69) |
p-value | |
---|---|---|---|---|
Age at baseline (years)* |
75.7 (5.4) | 74.8 (7.2) | 75.0 (7.7) | 0.61 |
Gender (% male) | 50% | 64.5% | 57.0% | 0.0070 |
Education (years)* | 15.6 (2.9) | 16.0 (2.9) | 15.1 (2.9) | 0.14 |
APOE ε4 presence (%) |
22 (23.9%) | 80 (53.7%) | 49 (71.0%) | <0.0001 |
ADAS* | 9.4(4.2) | 19.2 (6.1) | 29.1 (8.3) | <0.0001 |
APOE CSF levels (µg/ml)† |
6.9 (6.1–8.5) | 7.2 (5.4–8.5) | 6.1 (4.8–8.0) | 0.065 |
Aβ1–42 (pg/ml)† | 220.0 (161.0–252.5) | 144.0 (126.0–185.5) | 134.0 (122.0–162.0) | <0.0001 |
T-tau (pg/ml)† | 61.0 (48.0–84.5) | 87.0 (65.0–121.5) | 116.0 (81.0–157.8) | <0.0001 |
P-tau181 (pg/ml)† | 20.0 (16.5–29.5) | 35.5 (23.0–46.3) | 36.0 (29.0–49.0) | <0.0001 |
Mean (standard deviation);
Median (1st quartile-3rd quartile).