Table 3.

Association of CSF Apo-E levels and t-tau/Aβ_1–42 ratio with longitudinal MRI volume changes in a model adjusted for gender, APOE ε4presence, clinical diagnosis and intracranial volume.

Areas	CSF Apo-E				T-tau/Aβ1–42
	β	S.E.	t-value	p-value	β	S.E.	t-value	p-value
Fusiform	39.06	11.90	3.28	0.011	−74.64	12.87	−5.80	<0.0001
Inferior Parietal	51.59	15.80	3.26	0.011	−58.18	16.99	−3.43	0.0014
Inferior Temporal	43.48	14.09	3.09	0.014	−69.17	15.28	−4.53	<0.0001
Superior Frontal	70.40	23.51	2.99	0.014	−62.78	25.34	−2.48	0.0191
Precuneus	31.72	11.08	2.86	0.017	−36.10	11.95	−3.02	0.0047
Middle Frontal	66.07	23.93	2.76	0.019	−55.81	25.76	−2.17	0.0358
Entorhinal	8.09	3.15	2.57	0.027	−18.87	3.38	−5.59	<0.0001
Inferior Frontal	28.62	11.19	2.56	0.027	−14.85	11.99	−1.24	0.2161
Lateral Orbitofrontal	19.65	8.24	2.39	0.038	−21.10	8.88	−2.38	0.0220
Middle Temporal	34.43	14.77	2.33	0.040	−79.70	16.06	−4.96	<0.0001
Superior Parietal	30.53	14.55	2.10	0.066	−41.40	15.61	−2.65	0.0125
Medial Orbitofrontal	10.30	5.02	2.05	0.067	−23.18	5.38	−4.31	<0.0001
Superior Temporal	21.19	11.67	1.82	0.107	−54.94	12.58	−4.37	<0.0001
Anterior Cingulate	7.39	4.27	1.73	0.120	−11.03	4.57	−2.41	0.0213
Lingual	9.06	5.82	1.56	0.159	−17.60	6.22	−2.83	0.0079
Posterior Cingulate	5.54	3.99	1.39	0.206	−13.21	4.29	−3.08	0.0042
Parahippocampal	3.74	2.83	1.32	0.219	−15.61	3.03	−5.15	<0.0001
Cuneus	3.07	2.97	1.03	0.335	−5.52	3.17	−1.74	0.0906
Transverse Temporal	1.22	1.52	0.80	0.446	−2.06	1.62	−1.27	0.2133
Temporal Pole	1.33	2.18	0.61	0.544	−9.48	2.32	−4.09	0.0001

β: standardized coefficient; S.E.: Standard error.

P-values are adjusted for multiple comparisons.