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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Mar 10;6(3):298–315. doi: 10.1002/wnan.1263

FIGURE 2.

FIGURE 2

Methods of displaying antigen on the particle surface. A) Chemical conjugation uses chemical crosslinkers or biotin-streptavidin cross-bridges to link the desired peptide to the NP surface. B) Genetic insertion results in recombinant particles in which the peptide of interest is inserted into a coat protein and displayed on the surface of a VLP following successful translation.