Table 4. Clinical details of patients with autoimmune or severe atopic disease.
Case | Cardiac diagnosis | Autoimmune/Atopic disease | Transplant year | Transplant age (years) | Time transplant to symptoms (years) | ATG dose (mg/kg) | Immunosuppression Regimen | Tac level* (ng/ml), Median (IQR) | Rejection | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|
|
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Initial | At diagnosis | Current | Year one | After year one | ||||||||
1 | Dilated cardiomyopathy | Inflammatory bowel disease | 2002 | 0.4 | 5.5 | 10.5 | Tac, Aza | Tac, Aza | Tac, Aza | 10.3 (7.9-13.2) | 7 (4.8-10.7) | Yes |
2 | Dilated cardiomyopathy | Inflammatory bowel disease | 2004 | 0.4 | 4.8 | 12 | Tac, Aza | Tac, Aza | Tac, Aza | 9.6 (6.3-13.8) | 6.9 (5.6-8.9) | No |
2 | Cardiac fibroma | Chronic bullous disease of childhood & Inflammatory bowel disease | 2002 | 0.1 | 7.9 | 14 | Tac, MMF | Tac, MMF | Tac, Aza | 8.5 (7.1-11.5) | 6.3 (4.6-8.4) | No |
4 | Dilated cardiomyopathy | Eosinophilic colitis | 2001 | 0.3 | 4 | 13.7 | Tac, MMF | Tac, Aza | Tac, MMF | 12.4 (8.8-14.9) | 7.7 (5.8-10.3) | Yes |
5 | Dilated cardiomyopathy | Eosinophilic colitis & esophagitis | 2007 | 0.6 | 1.6 | 11.8 | Tac, MMF | Tac, MMF | Tac, Sir | 8 (6.1-10.9) | 7.5 (6.2-9.2) | Yes |
6 | Pulmonary atresia | Eosinophilic esophagitis | 2005 | 0.1 | 0.6 | 13.3 | Tac, MMF | Tac, MMF | Tac, MMF | 8 (6.4-9.3) | 5.7 (4.6-7.8) | No |
7 | Complex single ventricle | Eosinophilic esophagitis | 2004 | 5.1 | 7.3 | 3.8 | Tac, MMF | Tac, MMF | Tac, Sir | 8.7 (6-11.3) | 9.1 (6.7-12.5) | Yes |
Tacrolimus level divided from initial discharge until the end of the first year post-transplant and subsequent to the first year post-transplant, ATG - anti-thymocyte globulin, Aza - azathioprine, IQR - interquartile range, MMF - mycophenolate mofetil, Sir - sirolimus, Tac - tacrolimus