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. Author manuscript; available in PMC: 2015 Apr 10.
Published in final edited form as: Mol Cell. 2014 Mar 20;54(1):17–29. doi: 10.1016/j.molcel.2014.02.018

Figure 5. The ligand specificity domain has evolved under positive selection.

Figure 5

(A) Sliding window comparison of the dN/dS ratio between mouse and rat Naip2 genes. dN/dS ratios were calculated every 20 codons with a window size of 50 codons. Shown above is the domain structure of mouse NAIP2.

(B) Results of PAML analyses on the entire primate NAIP gene, the ligand specificity domain alone, and the entire gene outside the ligand specificity domain. The left column shows two times the log likelihood difference between a model that allows (M8) or disallows (M7) positive selection. The right column shows the statistical significance of support for the gene, or domain, having evolved under positive selection. Values in red indicate strong support for positive selection. Red triangles indicate primate NAIP codons (corresponding to mouse NAIP2 residues 941, 965 and 1049) identified as having evolved under recurrent positive selection with a posterior probability of >0.95. See also Figure S5.