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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Mol Psychiatry. 2013 Oct 15;19(12):1284–1294. doi: 10.1038/mp.2013.135

Figure 2. Long-term pharmacological stimulation of ghrelin receptor activity enhances fear memory without altering other stress hormones.

Figure 2

Rats received daily systemic injections of MK-0677 (MK: 5d), a GHSR-1a agonist, or saline (VEH: 5d) for five days at the endogenous ghrelin signaling nadir. (a) One group underwent auditory fear conditioning 24h following the final injection. Fear acquisition was assessed by monitoring freezing levels. (b) Conditional freezing to the tone was assessed in a novel context 48h following fear conditioning. A separate group was sacrificed 24h following the final injection and microdissections of hypothalamus and amygdala performed. Brain CRF levels were measured using ELISA (c, hypothalamus, d, basolateral complex of the amygdala). * p<0.05 in planned comparisons.