Table 3.

 Overview of prospective studies of pregnancy outcomes in women with chronic hypertension included in meta-analysis

Author, year published	Study years	Country	No of women	No of births	Multiple gestations included	Secondary causes of chronic hypertension excluded	Congenital abnormalities excluded	Definition of chronic hypertension*	Newcastle-Ottowa grade
Attolou et al, 199832	1995-96	Benin	64	64	No	Cardiac or renal disease excluded	No	2	7
Curet et al, 197933	1973-79	USA	66	72	Yes	“No diabetes, cardiac or renal disease”	No	1	6
Fleischer et al, 198634	1982-84	USA	55	55	No	No	No	1	6
Gant et al, 197735	?-1977	USA	63	63	No	“Essential hypertension only”	No	3	6
Hartikainen et al, 199836	1985-86	Finland	396	396	No	No	No	1	7
Inigo Riesgo et al, 200837	2001-07	Mexico	110	110	No	“Mild chronic hypertension without other disease”	No	1	6
Jacquemyn et al, 200638	2001-02	Belgium	2393	2393	No	No	No	1	7
Mabie et al, 198639	1980-84	USA	156	169	Yes	No	No	2	6
Onyiriuka and Okolo, 200540	1992-94	Nigeria	20	20	No	“Free of major diseases such as diabetes mellitus, sickle cell anaemia, renal failure and heart disease”	No	2	6
Ray, 200141	1986-95	Canada	459	459	No	No	No	1	7
Rey and Couturier, 199442	1987-91	Canada	298	Unknown	Unknown	No	No	1	7
Rey, 199743	1987-91	USA	208	208	Yes	Renal disease and pre-pregnancy diabetes excluded	No	1	7
Roncaglia et al, 200844	2000-06	Italy	182	182	No	Excluded proteinuria at first visit	Yes	1	7
Ruiz et al, 200145	1996-97	Mexico	66	66	No	No	No	5	7
Segel et al, 200146	1995-2001	USA	131	131	No	No	No	1	6
Sibai et al, 198347	1980-82	USA	211	215	No	No	No	6	6
Sibai et al, 198648	1978-84	USA	44	44	No	No	No	6	6
Sun et al, 200749	2001-05	China	121	121	No	No	No	2	7
Valsecchi et al, 199950	1993-96	Italy	26	26	No	No	No	3	6
Zeeman et al, 200451	1999-2002	USA	87	87	No	No	No	2	6

*1=systolic blood pressure >140 or diastolic blood pressure >90 mm Hg and/or history of hypertension; 2=diastolic blood pressure >90 mm Hg and/or history of hypertension; 3=history of hypertension before pregnancy or presence of hypertension before 20 weeks with no blood pressure definition; 4=blood pressure >140/90 mm Hg; 5=history of hypertension only; 6=antihypertensive drug treatment before 20 weeks; 7=other.