Figure 6.

Histologic images of right breast cancer. (A) Hematoxyline and eosin (H&E) staining photomicrograph of right breast cancer shows proliferation of high nuclear grade malignant ductal epithelial cells which represent ductal carcinoma in situ (white arrows) and portions of invasion under basement membrane mean invasive ductal carcinoma (black arrow) (H&E stain, × 40), Inset: Note tumor emboli in lymphatic channels that provide more chance of lymphangitic or hematogenous metastasis (H&E stain, × 40). (B-D) Immunohistochemical staining of surgical specimen is positive for estrogen receptor (×100) (B) and progesterone receptor (×100) (C), equivocal (2+) for human epidermal growth factor receptor 2 (×100) (D). Fluorescence in situ hybridization reveals negativity for HER2 (not shown).