Figure 7.

Histologic images of left breast cancer. (A, B) Hematoxyline and eosin (H&E) staining photomicrographs of left breast cancer demonstrate multifocal infiltrative distribution of tumor cells in periductal area under the basement membrane (arrows). Note that normal ductal epithelium without ductal carcinoma in situ component that often accompanies primary cancer (arrowheads) (H&E stain, A: ×20, B: ×100). (C-E) Immunohistochemistry results are positive for estrogen receptor (×100) (C) and progesterone receptor (×100) (D), and negative for human epidermal growth factor receptor 2 (× 100) (E). (F) Immunoperoxidase staining photomicrograph of left breast cancer shows E-cadherin expression that is lost in lobular carcinoma (Immunohistochemical stain for E-cadherin, × 100).