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. 2014 Apr 9;5:49. doi: 10.3389/fendo.2014.00049

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Copyright © 2014 Griebel, Ravinet-Trillou, Beeské, Avenet and Pichat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cumulative weight gain as calculated from mean weights of WT control, Cry1-, and Cry2-deficient mice under STD and HFD. (A) Cry1^+/+ (filled symbols) and Cry1^−/− (open symbols) mice, (B): Cry2^+/+ (filled symbols) and Cry2^−/− mice (open symbols), determined once a week, on STD (triangles) and HFD (circles) regimens. Cry1 group: n = 5 (Cry1^+/+-STD) and 5 (Cry1^−/−-STD) and n = 4 (Cry1^+/+-HFD) and 5 (Cry1^−/−-HFD); Cry2 group: n = 6 (Cry2^+/+-STD) and n = 7 (Cry2^−/−-STD), and n = 8 (Cry2^+/+-HFD) and n = 6 (Cry2^−/−-STD). *P < 0.05, ns P > 0.05 indicated for genotype comparison, two-way ANOVA for body weight with repeated measures on factor week. Values shown are mean ± SEM.