Table 5.

Volumes of total brain and subcortical ROIs in marijuana users (MJ) and healthy controls (CON)

	Controls		MJ		Variance accounted for by ICV		Variance accounted for by sex		Variance accounted for by group
	Mean	SD	Mean	SD	F	p	F	p	F	p
Total ICV	1460962.45	186411.89	1429117.14	191802.18	—	—	12.89	**	0.37	NS
Total brain	1228316.23	107399.90	1207892.96	107013.81	37.75	***	5.61	*	0.12	NS
Total gray	652429.33	58089.89	643401.98	58569.35	28.87	***	5.39	*	1.03	NS
Total white	575886.9	56070.39	564490.98	53863.34	25.21	***	2.91	NS	0.10	NS
R accumbens	675.4	100.22	709.4	103.8	0.05	NS	0.12	NS	1.35	NS
R amygdala	1713.2	222.24	1764.75	222.81	9.49	**	1.75	NS	1.47	NS
R caudate	3980.15	432.73	3936.7	393.26	3.04	NS	2.22	NS	0.03	NS
R putamen	5790.8	610.46	5811.65	605.85	1.14	NS	3.39	NS	0.05	NS
R thalamus	7737.45	1053.86	7496.6	1065.25	12.06	**	0.49	NS	0.45	NS
R hippocampus	4325.05	443.61	4340.5	440.4	13.47	**	1.58	NS	0.27	NS
L accumbens	541.35	88.87	607.95	86.24	0.28	NS	0.01	NS	4.66	*
L amygdala	1698.45	323.56	1711.35	323.03	1.19	NS	10.76	**	0.09	NS
L caudate	3989.55	372.12	3863.45	358.7	4.07	*	3.10	NS	0.85	NS
L putamen	6204.25	620.05	6171.9	622.58	2.36	NS	3.58	NS	0.00	NS
L thalamus	7698.95	950.39	7471.8	950.78	4.77	*	0.43	NS	0.51	NS
L hippocampus	4231.7	379.52	4209.2	380.75	7.36	*	0.96	NS	0.00	NS

Total brain is composed of gray matter + white matter + intraventricular CSF. All volumes are reported in cubic millimeters. All structures were entered into a univariate general linear model to examine how ICV, sex, and group (MJ or CON) affected variance of volumes of structures.

*p < 0.05;

**p < 0.01;

***p < 0.001, uncorrected for multiple comparisons.