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Model of how downregulated GLT-1 promotes reinstated heroin seeking due to increase synaptic glutamate spillover to extrasynaptic glutamate receptors. The size of the symbol indicates increased or reduced stimulation by glutamate (mGluR5 or GluN2B) or glutamate transport (GLT-1). The dashed line and smaller arrowhead signify reduced glutamate relative to the solid line and larger arrowhead in response to the same amount of synaptically released glutamate.
