Figure 8.

Modeling study of the effect of thalamic deafferentation on the neocortical slow oscillation. a, Slow oscillation in large-scale thalamocortical model. Rastergrams of PYs, INs, REs, and TCs (top). b, Examples of membrane voltage of PY neurons from selected columns and of a TC neuron in control condition. c, Removal of synaptic connectivity from TC neurons to the first four cortical columns (top) reduced active states occurrence. d, Examples of membrane voltage of pyramidal neurons from selected columns after removal of thalamic inputs. e, LFPs in deafferented columns 1–4 were reduced in amplitude compared with intact columns 5–8.