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. 2009 Jan 1;199(1):134–141. doi: 10.1086/594369

Figure 5.

Figure 5

Effect of lopinavir/ritonavir on Plasmodium yoelii liver burden. Mice were gavaged with lopinavir/ritonavir before being injected intravenously with 10,000 P. yoelii sporozoites. Mice were given vehicle (control), 100 mg/kg lopinavir with 50 mg/kg ritonavir once a day (100 mg/kg QD LPV/r), or 25 mg/kg lopinavir with 12.5 mg/kg ritonavir once a day (25 mg/kg QD LPV/r), the lowest dose that had a significant effect. All experiments were performed twice, with 5–6 mice per group per experiment. *P<.05 (statistically significant difference between the treated group and the control group).