FIG. 1.
Chromophobe tumor grade (CTG) system with hematoxylin and eosin staining (A, ×1,500), classic CTG 1 ChRCC with abundant clear cytoplasm and prominent cell membranes (B, ×1,500), CTG 2 ChRCC characterized by a higher nuclear to cytoplasmic ratio compared to CTG 1 (C, ×3,000), at higher magnification CTG 2, ChRCC has a crowded cellular appearance but does not show the spindling or degree of diffuse anaplasia of CTG 3 (D, ×600). Grade 3 ChRCC with sarcomatoid differentiation characterized by an associated malignant spindle cell proliferation. ChRCC, chromophobe subtype of renal cell carcinoma.