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. Author manuscript; available in PMC: 2015 Jan 7.
Published in final edited form as: Anal Chem. 2014 Jan 7;86(1):58–64. doi: 10.1021/ac403956k

Figure 1.

Figure 1

Transition from α-helix to β-sheet evidenced by the changes in chemical shifts of α-synuclein incubated in the presence of phospholipid. Expanded regions of 13C–13C 2D spectra of AS incubated in the presence of phospholipid for 0, 1, 2, 3, 6, and 11 days. Secondary chemical shifts of individual resonances are diagnostic of conformation. Reproduced from G. Comellas, L. R. Lemkau, D. H. Zhou, J. M. George, C. M. Rienstra, J Am Chem Soc 2012, 134. 5090-9, DOI: 10.1021/ja209019s. Copyright 2012 American Chemical Society.