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. 2014 Jan 22;39(6):1399–1408. doi: 10.1038/npp.2013.335

Figure 2.

Figure 2

Percent improvement of explorative depression and cognition composite scores from individual baseline. (a) Explorative depression composite. The dotted line denotes the estimated depression composite of healthy individuals within the lower normal range calculated by z-transformation and averaging the cutoffs 17-item Hamilton Depression Rating Scale (HDRS-17)=7, Beck Depression Inventory-21 (BDI-21)=7, global assessment of function (GAF)=70, and the mean World Health Organization Quality of Life BREF (WHOQOL-BREF) score in the Danish population (Noerholm et al, 2004). (b) Explorative Rey Auditory Verbal Learning Test (RAVLT) composite. This was obtained by summation of the four z-transformed RAVLT measures, addition of 10 to these summed score to obtain overall positive values, and calculation of percent change from individual baseline. P-values indicate the results of the analysis of covariance (ANCOVA) of the mean change from the individual baseline between the drug groups. The dotted line denotes the estimated RAVLT memory composite of healthy, age-matched individuals of average intelligence (Strauss et al, 2006). Mean and SEM are presented.