Figure 3.

Impaired fine motor control abilities in mice lacking secretin. Four behavior tasks were performed: (a) wire-hanging latency; (b) time to climb a vertical wire mesh; (c) time on a constant speed rotarod; (d) time on an accelerating rotarod. (a–d) Comparisons between Pur-Sct^−/−, Sct^fl/fl, and WT as well as Sct^−/− and Sctr^−/− mice. Pur-Sct^−/− exhibited significantly lower neuromuscular strength (a), fine motor control (b), balance functions, and motor learning (c, d). All of these abnormalities also occurred in Sct^−/− and Sctr^−/− (a–d). Similar performances were found in Sct^fl/fl and WT (a–d), indicating minimal behavioral changes in Sct^fl/fl. ***p<0.001 against WT animals using post-hoc test; N=25–30 per group; all values are expressed as the mean±SEM.