Figure 4.
Age-dependent effects of Purkinje-specific secretin knockout. (a) A full battery of developmental milestones for juvenile mice was checked after birth. Data are showed in aligned dot plot with medians±ranges in postnatal days. Accumulated frequencies of juveniles with positive surface righting (b) and negative geotaxis (c) reflexes were plotted against postnatal days. Age-dependent wire hanging (d) and accelerating rotarod (e) performance were examined in Pur-Sct−/− and Sctfl/fl littermates. *p<0.05; **p<0.01; ***p<0.001 using two-sample non-parametric K-S test in a–c and using post-hoc Bonferroni test followed two-way ANOVA in d and e. N=15–20 per group. All values in d and e are expressed as the mean±SEM.