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. 2014 Jan 15;39(6):1332–1339. doi: 10.1038/npp.2013.345

Table 1. Summary of Diffusion Tensor Imaging Studies in Patients with Major Depressive Disorder using Corrected Whole-Brain Analysis.

  Participants
Imaging parameters
    Findings after rigorous threshold
  Healthy control
MDD
             
Study n Age (mean (SD)) Gender (M/F) n Age (mean (SD)) Gender (M/F) Magnet strength DTI resolution (mm) Number of diffusion direction Number of average Data processing Analysis method Reduction Increase
Tha et al (2013) 19 36.5 (12.5) 13/6 19 38.6 (14.5) 12/7 1.5T 1.875 * 1.875 * 5 12 2 No distortion correction Study-specific template SPM VBM Bilateral frontal WM Anterior limbs of internal capsule Let putamen Right thalamus Bilateral cerebellar hemispheres  
Cole et al (2012) 66 50.4 (7.9) 23/43 66 48.6 (8.2) 30/36 1.5T 2.5 * 2.5 * 2.5 60 1 No distortion correction JHU DTI template FSL TBSSROI regions Splenium Genu and body of corpus callosum Bilateral superior longitudinal fassiculus anterior and posterior corona radiata Anterior and posterior limbs of internal capsule  
                             
Zhu et al (2011) 25 20.33 (1.68) 10/15 25 20.55 (1.86) 10/15 1.5T 2 * 2 * 4 12 1 No distortion correction MNI template FSL TBSS Left anterior limb of internal capsule Right parahippocampa gyrus Left posterior cingulate cortex  
Wu et al (2011) 21 30.4 (8.2) 9/12 23 31.4 (8.8) 10/13 1.5T 0.94 * 0.94 * 4 12 5 No distortion correction MNI template DTIStudio and SPM VBM Right superior longitudinal fassiculus Right middle frontal Left inferior parietal  
Korgaonkar et al (2011) 39 29.6 (46.2) 18/21 29 40.5 (15.8) 12/17 3.0T 1.72 * 1.72 * 2.5 42 1 No distortion correction MNI template FSL TBSS No difference between MDD vs controls Reduction between meloncholic and controls in corpus callosum, dosalateral prefontal, thalamic projection fiber  
Abe et al (2010) 42 48 (13.2) 22/20 21 48.1 (13.5) 11/10 1.5T 1.875 * 1.875 * 5 6 4 Image-based distorion correction Study-specific template FSL VBM No difference  
Kieseppa et al (2010) 20 42 (11.6) 10/10 16 48.4 (10.3) 2/14 1.5T 1.75 * 1.75 * 5 12 1 No distortion correction MNI template FSL TBSS No difference  
Cullen et al (2010) 14 16.81 (1.5) 6/8 14 16.79 (1.29) 4/10 3.0T 2 * 2 * 2 30 1 Field map distortion correction Study-specific template FSL TBSS No difference  
Blood et al (2010) 22 35.3 (11.6) 10/12 22 36.3 (12.1) 10/12 3.0T 2 * 2 * 2 6 6 No distortion correction MNI template FSL and Freesurfer ROI regions Dosallateral prefrontal cortex Left precentral gyrus Ventral tefmental area Substantia nigra Right calcarine cortex
Zou et al (2008) 45 31 (10.3) 15/30 45 33.2 (8.9) 15/30 3.0T 1.875 * 1.875 * 3 14 2 No distortion correction MNI template DTIStudio and SPM VBM Left anterior limb of internal capsule Left superior longitudinal fasciculus  
Ma et al (2007) 14 27.1 (6.7) 2/12 14 28.9 (8) 2/12 1.5T 1.875 * 1.875 * 4 12 5 No distortion correction MNI template SPM VBM Right middle frontal gyrus Left lateral occipitotempolar gyrus Subgyral WM of the right parietal lobe Right angular gyrus