Table 2. D2/D3 Binding Potential (BPND) in Striatal ROIs.
|
Controls |
ADHD |
|||||
|---|---|---|---|---|---|---|
| Placebo | d-Amph | Placebo vs d-amph | Placebo | d-Amph | Placebo vs d-amph | |
| AST (SD) | 3.00 (0.41) | 3.00 (0.49) | t(17)=−0.04; p=0.97 | 3.25 (0.35) | 3.04 (0.43) | t(14)=2.15; p<0.05 |
| SMST (SD) | 3.53 (0.47) | 3.41 (0.54) | t(17)=1.37; p=0.19 | 3.76 (0.49) | 3.37 (0.48) | t(14)=3.24; p<0.006 |
| LST (SD) | 3.26 (0.39) | 2.86 (0.47) | t(17)=5.32; p<0.0005 | 3.16 (0.53) | 2.85 (0.43) | t(14)=2.36; p<0.03 |
| AST vs LSTa | t(17)=3.52; p=0.003 | t(17)=1.34; p=0.12 | t(14)=0.81; p=0.43 | t(14)=2.31; p=0.04 | ||
| SMST vs LSTa | t(17)=2.86; p=0.01 | t(17)=5.87; p<0.005 | t(14)=5.21; p=0.005 | t(14)=5.16; p<0.005 | ||
| AST vs SMST | t(17)=9.11; p<0.0005 | t(17)=6.14; p<0.005 | t(14)=5.95; p<0.0005 | t(14)=4.87; p<0.005 | ||
Abbreviations: AST, associative ROI; LST, limbic ROI; SMST, sensorimotor ROI.
BPND values for control and ADHD groups on placebo and d-amph. Regional pattern of D2/D3 binding on placebo differed as a function of Group, as described by statistics provided in the last three rows.
a
The group × ROI interaction was driven by group differences in binding discrepancies between AST vs LST (F(1, 31)=7.20; p=0.01) and between SMST vs LST (F(1, 31)=4.86; p=0.04); pairwise comparisons among regions are Bonferroni corrected. Regional BPND on d-amph did not differ significantly as a function of group (ps>0.45).