Table 1.
Study group | Study type | Phenotype EPC | Main findings |
---|---|---|---|
Becchi et al. [15] | Case-control sepsis (n = 24) |
CD34+ KDR+ in isolated PBMC CD34+ KDR+ CD133+ in isolated CD34+ cells |
(i) Increased % EPC the first 72 h after sepsis (ii) EPC severe sepsis ≫ sepsis |
| |||
Cribbs et al. [16] | Case-control sepsis (n = 86) | CFU-EPC | (i) Decreased CFU-EPC in sepsis (ii) Inversely associated with SOFA |
| |||
Luo et al. [17] | MODS model in pigs (n = 20) | CD133+ CD34+ in WB CFU-EPC Migration to VEGF |
Decreased EPC, CFU-EPC and migratory function in MODS |
| |||
Mayr et al. [18] | LPS in healthy volunteers (n = 32) | CD34+ KDR+ CD133+ EPC in WB CFU-EPC |
(i) Decrease in EPC number with nadir at 6 h post LPS (ii) Decreased CFU-EPC nadir 4 h after LPS |
| |||
Patschan et al. [19] | Case-control sepsis (n = 40) | KDR+ CD133+ in isolated PBMC CFU-EPC |
(i) Increased % EPC in sepsis (ii) Decreased CFU-EPC in sepsis |
| |||
Rafat et al. [20] | Case-control sepsis (n = 32) | CD34+ KDR+ CD133+ in isolated PBMC | (i) Increased % EPC in sepsis (ii) Lower % EPC in nonsurvivors |
| |||
Schlichting et al. [21] | Case-control severe sepsis (n = 18) | CFU-EPC | No difference |
| |||
van Ierssel et al. [22] | Case-control severe sepsis (n = 30) | CD34+ KDR+ in WB Migration to SDF-1α and VEGF |
(i) Decreased absolute number (ii) Decreased migratory capacity (iii) Impending organ dysfunction the first week was associated with lower EPC and a trend to impaired migration |
CFU-EPC: EPC colony forming units; EPC: endothelial progenitor cells, LPS: lipopolysaccharides; MODS: multiorgan dysfunction syndrome; PBMC: peripheral blood mononuclear cells; SDF-1α: stromal derived factor 1 α; SOFA: sequential organ failure assessment; VEGF: vascular endothelial growth factor; WB: whole blood.