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. Author manuscript; available in PMC: 2014 Jun 30.
Published in final edited form as: Adv Drug Deliv Rev. 2013 Mar 22;65(7):905–911. doi: 10.1016/j.addr.2013.03.002

Figure 3.

Figure 3

Drug response as a system with interactions between the drug, disease, and body through PK-PD processes. Thus, translational research in drug discovery and development could be considered to be divided into three broad disciplines – translational physiology, pharmacology and pathology. Mechanism-based PK-PD modelling, by quantitatively combining system and drug-specific physiological, pharmacological and pathological properties, has the potential to facilitate translational research. Adapted from ref 28.