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. 2014 Mar 27;3(4):289–296. doi: 10.1242/bio.20146585

Fig. 1. Chemical structures of DIF-1, DIF-3, and Bu-DIF-3, and synthesis of BODIPY-conjugated compounds.

Fig. 1.

(A) DIF-1 [1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one] and DIF-3 [1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one] are endogenous factors in D. discoideum. Bu-DIF-3 (butoxy-DIF-3) [1-(3-chloro-2,6-dihydroxy-4-butoxyphenyl)hexan-1-one] is an artificially designed derivative of DIF-3. The order of anti-proliferative activity has been established as Bu-DIF-3>DIF-3>DIF-1 (Gokan et al., 2005). (B) BODIPY-DIF-3G and BODIPY-DIF-3R were synthesized as described in Materials and Methods. Molecular mass (Mr) of each compound is indicated in parentheses.