Skip to main content
. 2014 Mar 27;3(4):297–306. doi: 10.1242/bio.20146866

Fig. 1. Positions of selected sites in the receptor structure.

Fig. 1.

Schematic representation of the α-factor receptor shows the seven transmembrane domains (boxes) embedded in the cellular membrane (stippled) and joined by the extracellular N-terminal domain, the cytoplasmic C-terminal domain, the three extra-cellular loops and the three cytoplasmic loops. Ste2-S184R and Ste2-F204S receptors fail to bind α-factor (Dosil et al., 2000; Yesilaltay and Jenness, 2000). Ste2-L236H receptors bind α-factor and undergo ligand-mediated endocytosis, but they fail to generate intracellular signals that lead to cell division arrest and transcriptional activation (Schandel and Jenness, 1994). Ste2-T326 receptors are truncated at residue 326 and fail to undergo ligand-mediated endocytosis (Konopka et al., 1988; Schandel and Jenness, 1994); they lack the SINNDAKSS endocytosis signal sequence (Rohrer et al., 1993).