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. 2014 Apr 1;5:3584. doi: 10.1038/ncomms4584

Figure 1. Proportions of NLS in contemporary human populations.

Figure 1

(a) Schematic representation of genomic distance calculations between contemporary human populations and Neanderthals. The genomes of out-of-Africa individuals were compared with the genomes of individuals of purely African ancestry (YRI). Single nucleotide differences from the Neanderthal genotype in an African genome were referred to as ‘ABBA’, while sites with the Neanderthal genotype in an out-of-Africa genome were referred to as ‘BABA’. (b) Average proportions of NLS in contemporary African (AF), European (EU) and Asian (AS) populations calculated based on sequence data from the 1,000 genomes project13; blue: genome wide (n=1,158,559 sites), red: LCP genes (n=498 sites). The error bars show the s.d. of the NLS proportion estimates. (c) Genomic distances between 11 contemporary human populations and Neanderthals; blue, genome wide; red, LCP genes. The maximal bar length corresponds to a NLS frequency of 30%. Placement of ASW and CEU individuals in sub-Saharan Africa and Western Europe, respectively, reflects their approximate historical geographical origins rather than their present location.