Figure 5. GlcN extends life span independent of the hexosamine pathway.
(a) Schematic overview on initial enzymatic steps of GlcN metabolism (so-called hexosamine pathway), and the corresponding C. elegans orthologues. (b) Life span analysis in C. elegans treated with RNAi against F21D5.1 (phospho-acetyl-D-glucosamine-mutase) in the presence (red) and absence of GlcN (P<0.0001, log-rank test, n=1).