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. Author manuscript; available in PMC: 2014 Nov 13.
Published in final edited form as: Chem Rev. 2013 Sep 16;113(11):8423–8455. doi: 10.1021/cr400158h

Figure 6.

Figure 6

The CTD-interacting domain (CID). (a) Structures of the CID of Pcf11, Nrd1 and Scaf8 bound to CTD peptides. (b) Diagram showing the interaction of CID side chains with CTD residues. Black arrows indicate interactions with the ß-turn and preceding Tyr residue. Blue arrows indicate Scaf8 interactions with the downstream Tyr residue. Red arrows indicate interactions with phosphorylated Ser residues by Nrd1 and Scaf8. The position of these interactions is indicated by the same colors in part A. The wavey bond in the CTD peptide bound to Nrd1 indicates the cis conformation of this paptide bond. (c) Dotted lines indicate alternative binding modes for Pcf11 bound to a doubly phosphorylated CTD peptide. The solid line represents the interaction of SCAF8 with a doubly phosphorylated CTD repeat.