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. 2014 Mar 27;157(1):26–40. doi: 10.1016/j.cell.2014.03.005

Figure 1.

Figure 1

Subcellular RNA Localization in Diverse Cell Types

(A) β-actin mRNA localizes to the periphery of migrating fibroblasts (Lawrence and Singer, 1986).

(B) β-actin mRNA (magenta, in situ hybridization) localizes to the axonal growth cone of a retinal ganglion cell neuron from a cultured Xenopus laevis eye primordium and partially colocalizes with the dynamic microtubule cytoskeleton (green, anti-tyrosinated tubulin). Superresolution image acquired using a DeltaVision OMX 3D-Structured-Illumination Microscope (Applied Precision), with a 100× 1.4 NA oil objective. Extended focus image from deconvolved Z stack images acquired at 0.125 μm step size B. Lu and C.E.H., unpublished). Scale bar, 5 μm.