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. 2014 Mar 6;53(5):726–737. doi: 10.1016/j.molcel.2014.01.013

Figure 4.

Figure 4

MICU1 Regulates Both the Threshold and Activation of MCU

(A) [Ca2+]mt measurements in intact HeLa cells overexpressing MICU1 and challenged with maximal histamine stimulation.

(B) [Ca2+]mt measurements in control and MICU1-silenced HeLa cells.

(C) Resting mitochondrial calcium levels in control and MICU1-silenced HeLa cells evaluated through ratiometric imaging of the mitochondrial targeted GCaMP6m.

(D) [Ca2+]mt measurements in control and MICU1-silenced permeabilized HeLa cells perfused with 400 nM buffered [Ca2+].

Data are presented as mean ± SD. Descriptive statistics can be found in Table S1. ∗p < 0.05 compared to control.