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. 2014 Mar 6;53(5):726–737. doi: 10.1016/j.molcel.2014.01.013

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© 2014 Elsevier Inc. All rights reserved.

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Ca²⁺-Dependent Functional Effects of MICU1 and MICU2

(A) [Ca²⁺]_mt measurements in intact HeLa cells transfected with the indicated constructs or siRNA and challenged with maximal histamine stimulation.

(B) [Ca²⁺]_mt measurements in intact HeLa cells overexpressing MICU1 and/or MICU2 and challenged with maximal histamine stimulation.

(C) Resting mitochondrial calcium levels in control, MCU-, MCU- and MICU1-, or MCU- and MICU1- and MICU2-overexpressing HeLa cells, evaluated through ratiometric imaging of the mitochondrial targeted GCaMP6m.

(D) [Ca²⁺]_mt measurements in intact HeLa cells overexpressing MICU1^EFmut and/or MICU2^EFmut and challenged with maximal histamine stimulation.

Data are presented as mean ± SD. Descriptive statistics can be found in Table S1. ^∗p < 0.05 compared to control. See also Figure S6.