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. 2014 Feb;22(2):334–343. doi: 10.1016/j.joca.2013.12.009

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© 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

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Fig. 2 — Distribution of up- and down-regulated genes within enriched GO groups. Differentially expressed genes were classified according to their GO group. GO groups that were significantly enriched were selected and the number of genes within each group that were up- or down-regulated in damaged compared to undamaged cartilage was calculated. Genes were included if there expression was showed >2 fold change in expression in all nine individuals with P < 0.05. Unfilled bars represent genes that were expressed at a higher level y in damaged compared to undamaged cartilage. Shaded bars represent those expressed at a lower level in damaged compared to undamaged cartilage. ECR = Extracellular Region. ECM = Extracellular Matrix.