Table I.
The top 50 upregulated genes in damaged cartilage compared to undamaged cartilage
| Gene name | Gene symbol | Fold | P-value |
|---|---|---|---|
| Interleukin 11 | IL11 | 15.9 | 0.0109 |
| SRY (sex determining region Y)-box 11 | SOX11 | 8.66 | 0.0077 |
| Delta/notch-like EGF repeat containing | DNER | 8.15 | 0.0077 |
| Chromosome 15 open reading frame 48 | C15orf48 | 7.88 | 0.0077 |
| Chromosome 5 open reading frame 23 | C5orf23 | 6.98 | 0.0209 |
| GDNF family receptor alpha 2 | GFRA2 | 6.19 | 0.0077 |
| Chemokine (C-X-C motif) ligand 14 | CXCL14 | 6.17 | 0.0077 |
| UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1 | GALNTL1 | 5.98 | 0.0077 |
| Brain and acute leukaemia, cytoplasmic | BAALC | 5.60 | 0.0077 |
| Prostaglandin E receptor 1 (subtype EP1) | PTGER1 | 5.04 | 0.0209 |
| GDNF family receptor alpha 2 | GFRA2 | 4.96 | 0.0077 |
| Fibroblast growth factor 18 | FGF18 | 4.68 | 0.0077 |
| S100 calcium binding protein A2 | S100A2 | 4.41 | 0.0077 |
| Coagulation factor C homologue, cochlin | COCH | 4.33 | 0.0284 |
| Chloride intracellular channel 3 | CLIC3 | 4.23 | 0.0077 |
| Transglutaminase 2 | TGM2 | 4.10 | 0.0077 |
| Chloride channel Ka | CLCNKA | 3.98 | 0.0109 |
| KIAA1622 transcript variant 2 | KIAA1622 | 3.93 | 0.0077 |
| Glutamate receptor, ionotropic, AMPA 2 | GRIA2 | 3.88 | 0.0077 |
| Cartilage oligomeric matrix protein | COMP | 3.86 | 0.0077 |
| Urocanase domain containing 1 | UROC1 | 3.86 | 0.0152 |
| Growth differentiation factor 6 | GDF6 | 3.85 | 0.0152 |
| Angiopoietin-like 4 | ANGPTL4 | 3.84 | 0.0077 |
| Annexin A8 | ANXA8 | 3.81 | 0.0152 |
| Ring finger protein 152 | RNF152 | 3.77 | 0.0077 |
| Cytoplasmic FMR1 interacting protein 2 | CYFIP2 | 3.77 | 0.0077 |
| Olfactory-like receptor PJCG2 | OR7E13P | 3.77 | 0.0077 |
| Tumour necrosis factor receptor superfamily, member 11b | TNFRSF11B | 3.69 | 0.0077 |
| Rho guanine nucleotide exchange factor (GEF) 15 | ARHGEF15 | 3.63 | 0.0077 |
| Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | SERPINE2 | 3.62 | 0.0077 |
| GDNF family receptor alpha 2 | GFRA2 | 3.59 | 0.0284 |
| Heparan sulphate (glucosamine) 3-O-sulfotransferase 3A1 | HS3ST3A1 | 3.52 | 0.0077 |
| HtrA serine peptidase 3 | HTRA3 | 3.48 | 0.0077 |
| Progestin and adipoQ receptor family member IX | PAQR9 | 3.45 | 0.0077 |
| Laminin, beta 3 | LAMB3 | 3.44 | 0.0077 |
| LIM domain only 6 | LMO6 | 3.43 | 0.0077 |
| ADAMTS-like 2 | ADAMTSL2 | 3.40 | 0.0077 |
| BTB (POZ) domain containing 16 | BTBD16 | 3.34 | 0.0077 |
| Glucagon-like peptide 2 receptor | GLP2R | 3.32 | 0.0077 |
| cDNA FLJ41861 fis, clone NTONG2008672 | C1orf170 | 3.27 | 0.0152 |
| Follistatin-like 3 (secreted glycoprotein) | FSTL3 | 3.24 | 0.0077 |
| Syntaxin 1A (brain)] | STX1A | 3.23 | 0.0077 |
| HtrA serine peptidase 1 | HTRA1 | 3.23 | 0.0077 |
| Laminin, gamma 3 | LAMC3 | 3.20 | 0.0077 |
| Noggin | NOG | 3.18 | 0.0077 |
| Bone morphogenetic protein 6 | BMP6 | 3.13 | 0.0109 |
| Metallothionein 3 | MT3 | 3.10 | 0.0152 |
| Decay-accelerating factor 4ab | CD55 | 3.10 | 0.0077 |
| Syntaxin 1A | STX1A | 3.05 | 0.0077 |
| Cytokine receptor-like factor 1 | CRLF1 | 3.04 | 0.0109 |