Figure 1.

Diverse Types of Information Calculated Based on Data from Various Techniques about a Dynamic Complex

(A–C) Information based on MS techniques, including peptides indicating crosslinks, solvent exposure information from HDX-MS, and arrival time distributions from IM-MS that can be used to calculate CCSs (A), 3D density maps of two conformational states detected from cryo ET classifications (B), and atomic models of the complex resulting from X-ray crystallography, NMR spectroscopy, or structure prediction methods (C).

(D) The information can be combined to provide pseudo-atomic models of the complex in multiple conformations.