Figure 1.

Modelling the role of Brca2 in PDAC development. Key features and findings from the three genetically engineered mouse models (GEMMs) are summarized here, and described in the main text. (A) Skoulidis et al. uniquely employ a truncated Brca2Tr allele mimicking germline mutations in human mutation carriers expressed in all somatic tissues. In contrast, (B) Feldmann et al. and (C) Rowley et al. conditionally delete Brca2 in the pancreas alone. All three GEMMs introduce tissue‐specific alleles activating Kras or inactivating Trp53. It is important to note that the Brca2 alleles as well as the Trp53 alleles used in each model are distinct.