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Concentration-effect curves of trans-4,5,6 and transplatin in CH1 (top) and SW480 (bottom) cells. Cytotoxicity correlates with the steric hindrance of the substituents R (R = NMe2 in trans-4, NEt2 in trans-5, NC5H10 in trans-6 and cis-6).
Curves for transplatin are taken from Ref. [10].
