Table 1.
IC50 values (μM; mean ± standard deviation) of cis-1–6 and trans-1–8 in two cancer cell lines (CH1 and SW480).
|
1 |
2 |
3 |
4 |
|||||
|---|---|---|---|---|---|---|---|---|
| cis | trans | cis | trans | cis | trans | cis | trans | |
| CH1 | 2.7 ± 0.4 | 5.2 ± 1.1 | 3.0 ± 0.4 | 23 ± 4 | 4.4 ± 0.8 | 7.4 ± 1.3 | 21 ± 6 | 210 ± 70 |
| SW480 | 36 ± 2 | 36 ± 10 | 32 ± 7 | 62 ± 5 | 32 ± 5 | 19 ± 3 | 370 ± 40 | > 640 |
| 5 | 6 | 7 | 8 | cisplatin | transplatin | |||
| cis | trans | cis | trans | trans | trans | |||
| CH1 | 39 ± 12 | 25 ± 4 | 40 ± 2 | 8.2 ± 2 | 140 ± 40 | 330 ± 60 | 0.14 ± 0.03 | 15 ± 2 |
| SW480 | 42 ± 6 | 110 ± 20 | 46 ± 2 | 55 ± 1 | 241 ± 3 | > 640 | 3.3 ± 0.4 | 19 ± 3 |