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. 2014 Mar 31;8(1):24–28. doi: 10.3315/jdcr.2014.1166

Table 1. General characteristic of cases (in chronologic order).

Author Patient gender & age Anti-diabetics [Period before onset of BP] Diagnosis Treatment Outcome
Attaway
et al.
(2013)
M / 70 Sitagliptin + metformin 12 mo DIF: Linear IgG and linear C3 BMZ pattern Changed anti-hyperglycemic treatment on admission
MP 60 mg q8hr IV x 3 days, then prednisone 0.75 mg/kg bw/day with tapering after stable remission
Sustained remission after the sitagliptin was discontinued at 2 mo follow up
Aouidad
et al.
(2013)
M / 61 Vildagliptin + metformin 6 mo DIF: Linear IgG and linear C3 BMZ pattern Indirect IF positive Topical corticosteroid (clobetasol propionate) on a 15-wk tapering regimen Disappearance of the pruritus 1 wk after medication treatment halted
Sustained remission at 2 mo follow up
  M / 93 Sitagliptin + gliclazide 6 mo Indirect IF negative * Topical corticosteroid (clobetasol propionate) 2 months after first lesions appeared Refractory disease under topical treatment and sitagliptin therapy for 10 months
Partial remission 2 wk after stopping sitagliptin treatment
  M / 76 Sitagliptin + metformin 5 mo Indirect IF negative* Topical corticosteroid (clobetasol propionate) Delayed improvement of the eruption with topical treatment after 6 mo with persisting pruritus
Skandalis
et al.
(2012)
F / 78 Vildagliptin + metformin 13 mo DIF: Linear IgG and linear C3 BMZ pattern
Indirect IF positive
MP: 0.5 mg∕kg bw∕day, followed by MTX: 0.1 mg ∕ kg bw ∕ week with MP tapering after induction of stable remission
Delayed change of anti- hyperglycaemic treatment (after discharge)
Sustained remission at 384 mg prednisone equivalent cumulative dose
Refractory disease with slow tapering of MP
  F / 80 Sitagliptin + metformin 4 mo DIF: Linear BMZ C3 pattern
Indirect IF positive
MP: 0.5 mg/kg bw/day, followed by MTX: 0.1 mg/kg bw∕week MP tapering after induction of stable remission
Delayed change of anti- hyperglycaemic treatment (before discharge)
Sustained remission induced at 115 mg prednisone equivalent cumulative dose
Rash reduction of MP at 4 mg/day within 6 weeks
  F / 72 Vildagliptin + metformin 8 mo DIF: negative
Indirect IF positive
Change of anti-hyperglycaemic treatment on admission
Topical mometasone furoate 0.1% cream treatment only
Relapsed course under systemic corticosteroid pulses during a 4 mo period before admission
Sustained remission within the first wk (6 days) after withdrawal of gliptin with topical treatment only
  M / 67 Vildagliptin + metformin 10 mo DIF: Linear IgG and linear BMZ C3 pattern
Indirect IF negative
Change of anti-hyperglycemic treatment on admission
MP: 0.5 mg/kg bw/day
MP tapering after induction of stable remission
Relapsed course under interrupted glucocorticoid treatment courses during a 6 mo period prior to admit
Sustained remission 5 days after withdrawal of gliptin under treatment with MP (at cumulative dose 192 mg prednisone equivalent)
MP tapering to 4 mg/day without relapse
  M / 75 Vildagliptin + metformin 2 mo DIF: Linear IgG and linear BMZ C3 pattern
Indirect IF positive
Changed anti-hyperglycemic treatment on admission
MP: 0.5 mg/kg bw/day
MTX: 0.1 mg/kg bw/week
MP tapering after induction of stable remission
Gliptin treatment withdrawal 1 week before onset of anti-BP treatment with partial remission without anti-BP treatment at admission
Sustained BP remission under quickly tapered MP schedule (complete remission at 115 mg cumulative prednisone equivalent dose)
Pasmatzi
et al.
(2011) #
F / 59 Vildagliptin + metformin 2 mo DIF positive 0.5 mg/kg/day methylprednisolone on an 8-week tapering scheme Complete remission was achieved 10 weeks after the vildagliptin / metformin was discontinued
  M / 67 Vildagliptin + metformin 2 mo DIF positive 200 mg/day doxycycline for a period of 4 weeks Complete remission was achieved 8 weeks after the vildagliptin / metformin was discontinued
* It was implied but not explicitly stated that a skin biopsy was performed with linear IgG and BMZ C3 pattern.
# It was stated that histologic and immunofluorescence patterns from skin biopsy were consistent with BP but the exact studies done were not commented on.