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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Expert Rev Neurother. 2014 Apr;14(4):449–463. doi: 10.1586/14737175.2014.896199

Figure 5.

Figure 5

SPR characterization of binding of a monoclonal IgM, OMAB, to Aβ peptide monomers and oligomers. OMAB was immobilized on the chip followed by injections of (A) Aβ(1-40) monomers or (B) oligomers, or (C) Aβ(1-42) monomers or (D) oligomers. The dissociation curves show that monomers do not stay bound to the IgM very long (t1/2 = ~1 min), whereas the oligomers stay bound to the IgM for much longer (t1/2 = days, or longer), indicating preference for the toxic oligomers. Thus, these IgMs may help capture oligomers for immune system processing, or be used as a capture molecule in a detection scheme. Figure is from Lindhagen-Persson et al. [103]