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. 2014 Apr 16;9(4):e90617. doi: 10.1371/journal.pone.0090617

Figure 4. Y maze preference index.

Figure 4

Preference index for the Y maze spatial memory task on post-injury day (PID) 7 and 30. Separate ANOVAs were used to compare the preference index for the novel arm of the Y maze during the recall trial (i.e., 2nd trial). (A) Weight drop injury resulted in significant object memory impairment in TBI-Vehicle animals relative to the other three treatment groups on post-injury day (PID) 7. (B) On PID 30, mice in the TBI-Vehicle group performed significantly worse as compared to the Sham-Vehicle and TBI-Drug groups (p<0.05). The Sham-Drug group did not differ significantly from any of the other groups. N-Acetylcysteine + topiramate (Drug) was protective against injury-induced deficits in performance in spatial memory-dependent tasks. Animals in the TBI-Drug group performed similarly to Sham-Vehicle. Values represent the mean ± SEM. * p<0.05 compared to sham vehicle.