Table 1. Published studies examining the toxicology of artesunate (ART) and artemether (ARM).

Species	Drug	Dose and application method	Effect	Reference
Dogs	ARM	20 mg kg−1 per day, i.m. for 30 days	Axonal damage in the cerebellar roof, pontine and vestibular nuclei, and in the raphe/ paralemniscal region; hypochromic, microcytic anemia	Classen et al., 1999 [30]
Rats	ARM	25 mg kg−1 per day, i.m. for 7 days	Damage of trapezoid nuclei, abnormalities in balance and coordination	Akinlolu and Shokunbi, 2008 [41]
Mouse	ARM/ART	300 mg kg−1 per day, p.o. for 28 days	Balance/gait disturbances and mortality	Nontprasert et al., 2000 [42]
Monkeys	ART	40 mg kg−1 per day, p.o. for 14 days	Reduced reticulocyte count	Clark et al., 2008 [43]

i.m.  =  intramuscular injection; p.o.  =  oral administration.