Table 4. Severity of muscle tissue injury at the injection site following repeated ARM or peanut oil administration by intramuscular injection in dogs (dose: 6 mg kg⁻¹ for 13 weeks).

Week	Animal numbers (n)	ARM	Peanut oil control	Student’s t-test
W4	4	2.25±0.87	1.75±0.62	0.0409
W8	4	2.67±0.78	1.83±0.58	0.0086
W13	4	3.92±1.08	2.33±0.98	0.0070
W17	4	3.84±0.72	2.58±0.90	0.0015

Severity grades: 0 = no significant lesions; 1 = minimal; 2 = mild; 3 = moderate; 4 = marked; 5 = severe.