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. 2014 Apr 16;9(4):e94922. doi: 10.1371/journal.pone.0094922

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© 2014 Rossnagl et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) In the control group 13 lesions developed in the left tibia while in both experimental groups 11 developed in the left tibia. The percentages of mice with lesions in the left tibia is shown. n = 18, 14 and 17 mice. (B) The percentage of left tibia lesions in comparison to the total number of lesions is similar in both CT-experimental group pairs. n as in A. (C) Total bioluminescence signal per mouse expressed in relative light units (RLU) was similar between the control and the experimental groups at 7 weeks. n = 12, 11 and 15 mice. (D) Total bioluminescence signal per lesion was similar too. n as in C. (E) The size of the lytic lesions at 7 weeks was comparable. n as in A. (F) Survival curves of the control group (CT) and the experimental +5 min hematoma group shows that there is no difference in median survival (7.5 vs. 8.5 weeks, p = ns). n as in A. For ease of presentation CT was compared with the group with the seemingly larger median survival only.